TIF6/YPR016C Summary

TIF6 BASIC INFORMATION

Standard Name	TIF6 1
Systematic Name	YPR016C
Alias	CDC95 2
Feature Type	ORF, Verified
Description	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits (3)
Name Description	Translation Initiation Factor 1

GO Annotations	All TIF6 GO evidence and references
	View Computational GO annotations for TIF6
Molecular Function
Manually curated	ribosomal large subunit binding (IDA)
Biological Process
Manually curated	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IMP) ribosomal large subunit biogenesis (IMP, IPI) ribosomal subunit export from nucleus (IGI) rRNA processing (IGI)
Cellular Component
Manually curated	cytoplasm (IDA) nucleolus (IDA) nucleus (IDA) preribosome, large subunit precursor (IDA)
High-throughput	preribosome, large subunit precursor (IDA)

Mutant Phenotype	All TIF6 Phenotype details and references
Classical genetics
null	inviable
repressible	cell cycle progression in G1 phase: arrested
Large-scale survey
null	competitive fitness: decreased filamentous growth: decreased haploinsufficient invasive growth: absent inviable
repressible	cell cycle progression in G1 phase: abnormal

Interactions	TIF6 All interactions details and references
	236 total interaction(s) for 114 unique genes/features.
Physical Interactions	Affinity Capture-MS: 193 Affinity Capture-Western: 21 Biochemical Activity: 1 PCA: 5
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 4 Phenotypic Suppression: 4 Synthetic Growth Defect: 2 Synthetic Rescue: 4

Sequence Information

ChrXVI:593066 to 592329 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..738	593066..592329	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006220

TIF6 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for TIF6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TIF6]

1)	Si K and Maitra U (1999) The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor. Mol Cell Biol 19(2):1416-26
2)	Wood LC, et al. (1999) Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae. J Biol Chem 274(17):11653-9
3)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27

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