SUT2/YPR009W Summary Help

Standard Name SUT2 1
Systematic Name YPR009W
Feature Type ORF, Verified
Description Putative transcription factor of the Zn2Cys6 family; regulates sterol uptake under anaerobic conditions along with SUT1; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; SUT2 has a paralog, SUT1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Sterol UpTake 5
Chromosomal Location
ChrXVI:576552 to 577358 | ORF Map | GBrowse
Gene Ontology Annotations All SUT2 GO evidence and references
  View Computational GO annotations for SUT2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Large-scale survey
64 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 53
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1

Expression Summary
Length (a.a.) 268
Molecular Weight (Da) 30,257
Isoelectric Point (pI) 9.71
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:576552 to 577358 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..807 576552..577358 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006213
References cited on this page View Complete Literature Guide for SUT2
1) Ness F, et al.  (2001) SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells. Eur J Biochem 268(6):1585-95
2) Rutzler M, et al.  (2004) SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast. Eur J Biochem 271(7):1284-91
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Blanda C and Hofken T  (2013) Regulation of mating in the budding yeast Saccharomyces cerevisiae by the zinc cluster proteins Sut1 and Sut2. Biochem Biophys Res Commun 438(1):66-70
5) Bourot S and Karst F  (1995) Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Gene 165(1):97-102
6) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66