REC8/YPR007C Summary

REC8 BASIC INFORMATION

Standard Name	REC8 1
Systematic Name	YPR007C
Alias	SPO69 2
Feature Type	ORF, Verified
Description	Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p (1, 3)
Name Description	RECombination

GO Annotations	All REC8 GO evidence and references
	View Computational GO annotations for REC8
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	meiotic sister chromatid cohesion (IMP) reciprocal meiotic recombination (IMP) synaptonemal complex assembly (IMP)
Cellular Component
Manually curated	condensed nuclear chromosome, centromeric region (IDA)

Mutant Phenotype	All REC8 Phenotype details and references
Classical genetics
null	meiosis: abnormal meiotic recombination: decreased Zip1p distribution: abnormal
Large-scale survey
null	sporulation: decreased viable

Interactions	REC8 All interactions details and references
	17 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-Western: 2 Biochemical Activity: 1 Co-localization: 3 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Synthetic Growth Defect: 1

Sequence Information

ChrXVI:571375 to 569333 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2043	571375..569333	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006211

REC8 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for REC8

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for REC8]

1)	Klein F, et al. (1999) A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis. Cell 98(1):91-103
2)	Chu S, et al. (1998) The transcriptional program of sporulation in budding yeast. Science 282(5389):699-705
3)	Buonomo SB, et al. (2000) Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin. Cell 103(3):387-98

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