CIT3/YPR001W Summary Help

Standard Name CIT3 1
Systematic Name YPR001W
Feature Type ORF, Verified
Description Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate (1, 2)
Name Description CITrate synthase 1
Chromosomal Location
ChrXVI:556377 to 557837 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CIT3 GO evidence and references
  View Computational GO annotations for CIT3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
37 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 19
  • Phenotypic Enhancement: 2
  • Positive Genetic: 5
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 486
Molecular Weight (Da) 53,811
Isoelectric Point (pI) 8.74
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:556377 to 557837 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1461 556377..557837 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006205
References cited on this page View Complete Literature Guide for CIT3
1) Jia YK, et al.  (1997) The CIT3 gene of Saccharomyces cerevisiae encodes a second mitochondrial isoform of citrate synthase. Mol Microbiol 24(1):53-9
2) Graybill ER, et al.  (2007) Functional comparison of citrate synthase isoforms from S. cerevisiae. Arch Biochem Biophys 465(1):26-37