SAM3/YPL274W Summary

SAM3 BASIC INFORMATION

Standard Name	SAM3
Systematic Name	YPL274W
Feature Type	ORF, Verified
Description	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p (1)
Name Description	S-AdenosylMethionine metabolism

GO Annotations	All SAM3 GO evidence and references
	View Computational GO annotations for SAM3
Molecular Function
Manually curated	putrescine transmembrane transporter activity (IDA, IMP) S-adenosylmethionine transmembrane transporter activity (IMP, ISS) spermidine transmembrane transporter activity (IDA, IMP)
Biological Process
Manually curated	putrescine transport (IDA, IMP) S-adenosylmethionine transport (IMP) spermidine transport (IDA, IMP)
Cellular Component
Manually curated	plasma membrane (IDA, IMP, ISS)

Mutant Phenotype	All SAM3 Phenotype details and references
Classical genetics
null	nutrient uptake: decreased resistance to Sinefungin: increased resistance to sinefungin: increased utilization of sulfur source: decreased
overexpression	nutrient uptake: increased resistance to sinefungin: decreased
reduction of function	resistance to sinefungin: increased resistance to Sinefungin: increased utilization of sulfur source: decreased
Large-scale survey
null	viable

Interactions	SAM3 All interactions details and references
	26 total interaction(s) for 24 unique genes/features.
Physical Interactions	Two-hybrid: 22
Genetic Interactions	Phenotypic Enhancement: 4

Sequence Information

ChrXVI:22938 to 24701 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1764	22938..24701	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000006195

SAM3 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SAM3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SAM3]

1)	Rouillon A, et al. (1999) Transport of sulfonium compounds. Characterization of the s-adenosylmethionine and s-methylmethionine permeases from the yeast Saccharomyces cerevisiae. J Biol Chem 274(40):28096-105

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.