SAM4/YPL273W Summary Help

Standard Name SAM4 1
Systematic Name YPL273W
Feature Type ORF, Verified
Description S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication (1, 2)
Name Description S-AdenosylMethionine metabolism 1
Chromosomal Location
ChrXVI:25087 to 26064 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SAM4 GO evidence and references
  View Computational GO annotations for SAM4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
14 total interaction(s) for 13 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2

Genetic Interactions
  • Negative Genetic: 10
  • Phenotypic Enhancement: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 325
Molecular Weight (Da) 36,668
Isoelectric Point (pI) 4.98
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:25087 to 26064 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..978 25087..26064 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006194
References cited on this page View Complete Literature Guide for SAM4
1) Thomas D, et al.  (2000) Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells. J Biol Chem 275(52):40718-24
2) Thomas D and Surdin-Kerjan Y  (1991) The synthesis of the two S-adenosyl-methionine synthetases is differently regulated in Saccharomyces cerevisiae. Mol Gen Genet 226(1-2):224-32