Standard Name	KAR9 1
Systematic Name	YPL269W
Feature Type	ORF, Verified
Description	Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase (1, 2)
Name Description	KARyogamy 1

Chromosomal Location	ChrXVI:33013 to 34947 | ORF Map | GBrowse

	View Computational GO annotations for KAR9
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	establishment of spindle localization (IMP) nuclear migration along microtubule (IMP)
Cellular Component
Manually curated	cell cortex (IDA) mating projection tip (IDA) spindle pole body (IDA)

Classical genetics
null	Spc42p distribution: abnormal spindle morphology: abnormal
reduction of function	cytoskeleton morphology: abnormal nuclear fusion during mating: abnormal spindle morphology: abnormal
Large-scale survey
null	competitive fitness: decreased competitive fitness: increased dessication resistance: decreased resistance to cycloheximide: decreased resistance to mefloquine: decreased resistance to benomyl: decreased stress resistance: decreased vegetative growth: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	243 total interaction(s) for 108 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 15 Biochemical Activity: 2 Co-fractionation: 1 Co-localization: 1 Reconstituted Complex: 5 Two-hybrid: 28
Genetic Interactions	Negative Genetic: 60 Phenotypic Enhancement: 13 Phenotypic Suppression: 2 Positive Genetic: 3 Synthetic Growth Defect: 61 Synthetic Lethality: 49 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:33013 to 34947 | ORF Map | GBrowse
Last Update	Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1935 33013..34947 1996-07-31 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006190