ACM1/YPL267W Summary Help

Standard Name ACM1 1
Systematic Name YPL267W
Feature Type ORF, Verified
Description Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C (1, 2, 3, 4)
Name Description APC/C[Cdh1] Modulator 1
Chromosomal Location
ChrXVI:38169 to 38798 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ACM1 GO evidence and references
  View Computational GO annotations for ACM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 79 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
55 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-Western: 11
  • Biochemical Activity: 9
  • Co-crystal Structure: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 8
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 209
Molecular Weight (Da) 23,870
Isoelectric Point (pI) 10.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:38169 to 38798 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..630 38169..38798 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006188
References cited on this page View Complete Literature Guide for ACM1
1) Martinez JS, et al.  (2006) Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol 26(24):9162-76
2) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
3) Enquist-Newman M, et al.  (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46
4) Ostapenko D, et al.  (2008) Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol 28(15):4653-64