APM1/YPL259C Summary

APM1 BASIC INFORMATION

Standard Name	APM1 1
Systematic Name	YPL259C
Alias	YAP54 1
Feature Type	ORF, Verified
Description	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting (1, 2)
Name Description	clathrin Adaptor Protein complex Medium chain 1

GO Annotations	All APM1 GO evidence and references
	View Computational GO annotations for APM1
Molecular Function
Manually curated	clathrin binding (IPI, ISS)
Biological Process
Manually curated	Golgi to vacuole transport (IMP) vesicle-mediated transport (IPI, ISS)
Cellular Component
Manually curated	AP-1 adaptor complex (IPI, ISS)

Mutant Phenotype	All APM1 Phenotype details and references
Classical genetics
null	vacuolar transport: abnormal
Large-scale survey
null	acid pH resistance: decreased resistance to rapamycin: decreased resistance to wortmannin: normal resistance to hygromycin B: decreased viable

Interactions	APM1 All interactions details and references
	55 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 37 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 PCA: 1 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 2 Synthetic Growth Defect: 5 Synthetic Rescue: 1

Sequence Information

ChrXVI:52671 to 51244 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1428	52671..51244	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006180

APM1 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for APM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for APM1]

1)	Nakayama Y, et al. (1991) The medium chains of the mammalian clathrin-associated proteins have a homolog in yeast. Eur J Biochem 202(2):569-74
2)	Stepp JD, et al. (1995) A late Golgi sorting function for Saccharomyces cerevisiae Apm1p, but not for Apm2p, a second yeast clathrin AP medium chain-related protein. Mol Biol Cell 6(1):41-58

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.