GYP5/YPL249C Summary

GYP5 BASIC INFORMATION

Standard Name	GYP5
Systematic Name	YPL249C
Feature Type	ORF, Verified
Description	GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p (1, 2, 3)
Name Description	Gtpase-activating protein for Ypt Proteins 2

GO Annotations	All GYP5 GO evidence and references
	View Computational GO annotations for GYP5
Molecular Function
Manually curated	Rab GTPase activator activity (IGI, IPI, ISS)
Biological Process
Manually curated	ER to Golgi vesicle-mediated transport (IGI, IPI) vesicle-mediated transport (IGI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) cytosol (IDA) Golgi-associated vesicle (IDA) incipient cellular bud site (IDA) membrane fraction (IDA) plasma membrane (IDA) soluble fraction (IDA)

Mutant Phenotype	All GYP5 Phenotype details and references
Large-scale survey
null	viable

Interactions	GYP5 All interactions details and references
	38 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-Western: 3 Biochemical Activity: 1 Co-fractionation: 3 Co-localization: 1 Far Western: 3 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 14
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Phenotypic Enhancement: 1 Synthetic Growth Defect: 1

Sequence Information

ChrXVI:79353 to 76669 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2685	79353..76669	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006170

GYP5 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for GYP5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for GYP5]

1)	Bon E, et al. (2000) A network of proteins around Rvs167p and Rvs161p, two proteins related to the yeast actin cytoskeleton. Yeast 16(13):1229-41
2)	De Antoni A, et al. (2002) Significance of GTP hydrolysis in Ypt1p-regulated endoplasmic reticulum to Golgi transport revealed by the analysis of two novel Ypt1-GAPs. J Biol Chem 277(43):41023-31
3)	Friesen H, et al. (2005) Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking. Genetics 170(2):555-68

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