IQG1/YPL242C Summary

IQG1 BASIC INFORMATION

Standard Name	IQG1
Systematic Name	YPL242C
Alias	CYK1
Feature Type	ORF, Verified
Description	Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family (1, 2)
Name Description	IQGAP-related protein 2

GO Annotations	All IQG1 GO evidence and references
	View Computational GO annotations for IQG1
Molecular Function
Manually curated	cytoskeletal protein binding (IPI)
Biological Process
Manually curated	actin filament organization (IPI) cytokinesis (IMP) response to osmotic stress (TAS)
Cellular Component
Manually curated	cellular bud neck contractile ring (TAS)

Mutant Phenotype	All IQG1 Phenotype details and references
Classical genetics
overexpression	bipolar budding pattern: increased bud neck morphology: abnormal cellular morphology: abnormal nuclear morphology: abnormal
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased
repressible	mitochondrial morphology: abnormal

Interactions	IQG1 All interactions details and references
	43 total interaction(s) for 23 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 9 Biochemical Activity: 1 Co-localization: 1 FRET: 1 PCA: 3 Reconstituted Complex: 1 Two-hybrid: 5
Genetic Interactions	Dosage Lethality: 2 Dosage Rescue: 6 Phenotypic Enhancement: 2 Phenotypic Suppression: 1 Synthetic Growth Defect: 3 Synthetic Lethality: 5 Synthetic Rescue: 1

Sequence Information

ChrXVI:95109 to 90622 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4488	95109..90622	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006163

IQG1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IQG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IQG1]

1)	Lippincott J and Li R (1998) Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol 140(2):355-66
2)	Epp JA and Chant J (1997) An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast. Curr Biol 7(12):921-9

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