YAR1/YPL239W Summary Help

Standard Name YAR1 1
Systematic Name YPL239W
Feature Type ORF, Verified
Description Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock (1, 2, 3, 4)
Name Description Yeast Ankyrin Repeat 1
Chromosomal Location
ChrXVI:99484 to 100086 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All YAR1 GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 11 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
89 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Co-purification: 1
  • Protein-peptide: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 60
  • Positive Genetic: 12
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 200
Molecular Weight (Da) 22,355
Isoelectric Point (pI) 4.2
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:99484 to 100086 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..603 99484..100086 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006160
References cited on this page View Complete Literature Guide for YAR1
1) Lycan DE, et al.  (1996) A new Saccharomyces cerevisiae ankyrin repeat-encoding gene required for a normal rate of cell proliferation. Gene 171(1):33-40
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Loar JW, et al.  (2004) Genetic and biochemical interactions among Yar1, Ltv1 and Rps3 define novel links between environmental stress and ribosome biogenesis in Saccharomyces cerevisiae. Genetics 168(4):1877-89
4) Koch B, et al.  (2012) Yar1 protects the ribosomal protein Rps3 from aggregation. J Biol Chem 287(26):21806-15