NSL1/YPL233W Summary Help

Standard Name NSL1 1
Systematic Name YPL233W
Feature Type ORF, Verified
Description Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND) (1)
Name Description Nnf1 Synthetic Lethal 1
Chromosomal Location
ChrXVI:106172 to 106822 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NSL1 GO evidence and references
  View Computational GO annotations for NSL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
conditional
Large-scale survey
conditional
null
reduction of function
Resources
128 total interaction(s) for 84 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 46
  • Affinity Capture-Western: 10
  • Co-crystal Structure: 1
  • Co-fractionation: 1
  • PCA: 2
  • Reconstituted Complex: 6
  • Two-hybrid: 4

Genetic Interactions
  • Dosage Rescue: 7
  • Negative Genetic: 44
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 216
Molecular Weight (Da) 25,416
Isoelectric Point (pI) 4.52
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:106172 to 106822 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..651 106172..106822 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006154
References cited on this page View Complete Literature Guide for NSL1
1) Euskirchen GM  (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40