LEA1/YPL213W Summary Help

Standard Name LEA1 1
Systematic Name YPL213W
Feature Type ORF, Verified
Description Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein (1)
Name Description Looks Exceptionally like U2A 1
Chromosomal Location
ChrXVI:150614 to 151330 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All LEA1 GO evidence and references
Molecular Function
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
519 total interaction(s) for 289 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 201
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 3
  • Co-localization: 1
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 227
  • Positive Genetic: 41
  • Synthetic Growth Defect: 22
  • Synthetic Lethality: 16

Resources
Expression Summary
histogram
Resources
Length (a.a.) 238
Molecular Weight (Da) 27,193
Isoelectric Point (pI) 7.64
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:150614 to 151330 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..717 150614..151330 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006134
References cited on this page View Complete Literature Guide for LEA1
1) Caspary F and Seraphin B  (1998) The yeast U2A'/U2B complex is required for pre-spliceosome formation. EMBO J 17(21):6348-58