LEA1/YPL213W Summary

LEA1 BASIC INFORMATION

Standard Name	LEA1
Systematic Name	YPL213W
Feature Type	ORF, Verified
Description	Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; invovled in telomere maintenance; putative homolog of human U2A' snRNP protein (1, 2)
Name Description	Looks Exceptionally like U2A 1

GO Annotations	All LEA1 GO evidence and references
	View Computational GO annotations for LEA1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IMP)
Cellular Component
Manually curated	U2 snRNP (IDA, IPI) U2-type prespliceosome (IDA)
High-throughput	cytoplasm (IDA)

Mutant Phenotype	All LEA1 Phenotype details and references
Large-scale survey
null	acid pH resistance: decreased chitin deposition: normal competitive fitness: decreased heat sensitivity: increased resistance to Calcofluor White: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to ethanol: decreased resistance to hygromycin B: decreased resistance to oleate: decreased telomere length: increased viable

Interactions	LEA1 All interactions details and references
	211 total interaction(s) for 120 unique genes/features.
Physical Interactions	Affinity Capture-MS: 117 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Co-localization: 1 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Phenotypic Enhancement: 35 Phenotypic Suppression: 27 Synthetic Growth Defect: 13 Synthetic Lethality: 10

Sequence Information

ChrXVI:150613 to 151329 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..717	150613..151329	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006134

LEA1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for LEA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for LEA1]

1)	Caspary F and Seraphin B (1998) The yeast U2A'/U2B complex is required for pre-spliceosome formation. EMBO J 17(21):6348-58
2)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63

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