Standard Name	APL5 1
Systematic Name	YPL195W
Alias	YKS4 2
Feature Type	ORF, Verified
Description	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function (1, 2, 3)
Name Description	clathrin Adaptor Protein complex Large chain 1

Chromosomal Location	ChrXVI:176223 to 179021 | ORF Map | GBrowse

	View Computational GO annotations for APL5
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	Golgi to vacuole transport (IMP) protein targeting to vacuole (IMP)
Cellular Component
Manually curated	AP-3 adaptor complex (IMP)

Classical genetics
null	metal resistance: decreased GFP-Nyv1p distribution: abnormal alkaline phosphatase modification: decreased
Large-scale survey
null	acid pH resistance: decreased polyphosphate accumulation: abnormal inositol excretion: increased dessication resistance: decreased haploinsufficient Fus-Mid-GFP distribution: abnormal Pho8p (ALP) modification: decreased resistance to bleomycin: decreased resistance to PM02734: decreased resistance to hydroxyurea: increased resistance to cycloheximide: increased resistance to camptothecin: increased resistance to nickel sulfate: increased resistance to caffeine: decreased resistance to sirolimus: increased resistance to fluconazole: decreased resistance to sirolimus: decreased resistance to cycloheximide: decreased resistance to mefloquine: decreased resistance to wortmannin: increased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	211 total interaction(s) for 109 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 Co-purification: 1 PCA: 1 Reconstituted Complex: 11 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 141 Positive Genetic: 16 Synthetic Growth Defect: 6 Synthetic Lethality: 3 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:176223 to 179021 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2799 176223..179021 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006116