PRM3/YPL192C Summary Help

Standard Name PRM3 1
Systematic Name YPL192C
Feature Type ORF, Verified
Description Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body (1, 2, 3, 4)
Name Description Pheromone-Regulated Membrane protein 1
Chromosomal Location
ChrXVI:183056 to 182655 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All PRM3 GO evidence and references
  View Computational GO annotations for PRM3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
conditional
null
overexpression
reduction of function
Large-scale survey
null
Resources
27 total interaction(s) for 21 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 1
  • Co-localization: 1
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 11
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 133
Molecular Weight (Da) 14,428
Isoelectric Point (pI) 11.11
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:183056 to 182655 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..402 183056..182655 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006113
References cited on this page View Complete Literature Guide for PRM3
1) Heiman MG and Walter P  (2000) Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating. J Cell Biol 151(3):719-30
2) White JM and Rose MD  (2001) Yeast mating: getting close to membrane merger. Curr Biol 11(1):R16-20
3) Beilharz T, et al.  (2003) Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae. J Biol Chem 278(10):8219-23
4) Shen S, et al.  (2009) Prm3p is a pheromone-induced peripheral nuclear envelope protein required for yeast nuclear fusion. Mol Biol Cell 20(9):2438-50