NAB3/YPL190C Summary

NAB3 BASIC INFORMATION

Standard Name	NAB3 1
Systematic Name	YPL190C
Alias	HMD1
Feature Type	ORF, Verified
Description	Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p (1, 2, 3)
Name Description	Nuclear polyAdenylated RNA-Binding 1

GO Annotations	All NAB3 GO evidence and references
	View Computational GO annotations for NAB3
Molecular Function
Manually curated	poly(A) RNA binding (IDA)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (IGI, IPI) termination of RNA polymerase II transcription, poly(A)-independent (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Mutant Phenotype	All NAB3 Phenotype details and references
Classical genetics
conditional	cryptic unstable transcripts (CUTs) accumulation: increased
null	inviable
repressible	NEL025c mRNA accumulation: abnormal
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased

Interactions	NAB3 All interactions details and references
	59 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 40 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Biochemical Activity: 6 PCA: 3 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 2 Synthetic Rescue: 1

Sequence Information

ChrXVI:187724 to 185316 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2409	187724..185316	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006111

NAB3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NAB3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NAB3]

1)	Wilson SM, et al. (1994) Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. J Cell Biol 127(5):1173-84
2)	Conrad NK, et al. (2000) A yeast heterogeneous nuclear ribonucleoprotein complex associated with RNA polymerase II. Genetics 154(2):557-71
3)	Carroll KL, et al. (2004) Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts. Mol Cell Biol 24(14):6241-52

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