MRN1/YPL184C Summary Help

Standard Name MRN1 1
Systematic Name YPL184C
Alias PTR69 2
Feature Type ORF, Verified
Description RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation (2, 3)
Name Description Multicopy supressor of rsc nhp6 3, 4
Chromosomal Location
ChrXVI:197788 to 195950 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MRN1 GO evidence and references
  View Computational GO annotations for MRN1
Molecular Function
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
52 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 7
  • Negative Genetic: 25
  • Positive Genetic: 4
  • Synthetic Growth Defect: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 612
Molecular Weight (Da) 68,663
Isoelectric Point (pI) 5.74
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:197788 to 195950 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1839 197788..195950 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006105
References cited on this page View Complete Literature Guide for MRN1
1) Hughes TR and Pena-Castillo L  (2007) Why are there still over 1000 uncharacterized yeast genes? Genetics 176(1):7-14
2) Hogan DJ, et al.  (2008) Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system. PLoS Biol 6(10):e255
3) During L, et al.  (2012) MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation. PLoS One 7(9):e44373
4) Holmberg S  (2006) personal communication