MRN1/YPL184C Summary Help

Standard Name MRN1 1
Systematic Name YPL184C
Alias PTR69 2
Feature Type ORF, Verified
Description RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation (2, 3)
Name Description Multicopy supressor of rsc nhp6 3, 4
Chromosomal Location
ChrXVI:197788 to 195950 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MRN1 GO evidence and references
  View Computational GO annotations for MRN1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 69 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
50 total interaction(s) for 45 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 7
  • Negative Genetic: 25
  • Positive Genetic: 4
  • Synthetic Growth Defect: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 612
Molecular Weight (Da) 68,663
Isoelectric Point (pI) 5.74
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:197788 to 195950 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1839 197788..195950 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006105
References cited on this page View Complete Literature Guide for MRN1
1) Pena-Castillo L and Hughes TR  (2007) Why are there still over 1000 uncharacterized yeast genes? Genetics 176(1):7-14
2) Hogan DJ, et al.  (2008) Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system. PLoS Biol 6(10):e255
3) During L, et al.  (2012) MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation. PLoS One 7(9):e44373
4) Holmberg S  (2006) personal communication