CBC2/YPL178W Summary

CBC2 BASIC INFORMATION

Standard Name	CBC2 1
Systematic Name	YPL178W
Alias	MUD13 , SAE1 , CBP20
Feature Type	ORF, Verified
Description	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif (2, 3)
Name Description	Cap Binding Complex 1

GO Annotations	All CBC2 GO evidence and references
	View Computational GO annotations for CBC2
Molecular Function
Manually curated	RNA cap binding (IDA, ISS)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IMP)
Cellular Component
Manually curated	commitment complex (IDA) nuclear cap binding complex (IDA)

Mutant Phenotype	All CBC2 Phenotype details and references
Classical genetics
null	resistance to 6-azauridine: decreased resistance to mycophenolic acid: decreased
unspecified	meiotic recombination: decreased sporulation: absent
Large-scale survey
null	glycogen accumulation: increased polyphosphate accumulation: abnormal competitive fitness: decreased fermentative growth: decreased rate hyperosmotic stress resistance: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to doxorubicin: decreased sporulation: absent telomere length: increased viable

Interactions	CBC2 All interactions details and references
	181 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 71 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 PCA: 1 Reconstituted Complex: 2 Two-hybrid: 3
Genetic Interactions	Phenotypic Enhancement: 41 Phenotypic Suppression: 27 Synthetic Growth Defect: 15 Synthetic Lethality: 16 Synthetic Rescue: 3

Sequence Information

ChrXVI:212157 to 212783 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..627	212157..212783	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006099

CBC2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CBC2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CBC2]

1)	Das B, et al. (2000) The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation. Mol Cell Biol 20(8):2827-38
2)	Shen EC, et al. (2000) 7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. J Biol Chem 275(31):23718-24
3)	Colot HV, et al. (1996) The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex. Genes Dev 10(13):1699-708

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