CUP9/YPL177C Summary

CUP9 BASIC INFORMATION

Standard Name	CUP9
Systematic Name	YPL177C
Feature Type	ORF, Verified
Description	Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription (1, 2, 3)

GO Annotations	All CUP9 GO evidence and references
	View Computational GO annotations for CUP9
Molecular Function
Manually curated	specific RNA polymerase II transcription factor activity (ISS) transcription activator activity (IMP) transcription repressor activity (IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular copper ion homeostasis (IMP) regulation of transcription (IMP) transcription initiation from RNA polymerase II promoter (ISS)
Cellular Component
Manually curated	nucleus (ISS)

Regulatory Role
Regulatory modules	predicted: stressResponse ( 421 )

Mutant Phenotype	All CUP9 Phenotype details and references
Large-scale survey
null	viable

Interactions	CUP9 All interactions details and references
	15 total interaction(s) for 9 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 3 Reconstituted Complex: 3
Genetic Interactions	Dosage Rescue: 1 Phenotypic Suppression: 2 Synthetic Growth Defect: 1

Sequence Information

ChrXVI:213961 to 213041 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..921	213961..213041	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006098

CUP9 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CUP9

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CUP9]

1)	Byrd C, et al. (1998) The N-end rule pathway controls the import of peptides through degradation of a transcriptional repressor. EMBO J 17(1):269-77
2)	Turner GC, et al. (2000) Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway. Nature 405(6786):579-83
3)	Knight SA, et al. (1994) Identification and analysis of a Saccharomyces cerevisiae copper homeostasis gene encoding a homeodomain protein. Mol Cell Biol 14(12):7792-804

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