DAP1/YPL170W Summary Help

Standard Name DAP1 1
Systematic Name YPL170W
Feature Type ORF, Verified
Description Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis (1, 2)
Name Description DAmage resistance Protein 1
Chromosomal Location
ChrXVI:228314 to 228772 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DAP1 GO evidence and references
  View Computational GO annotations for DAP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
repressible
Resources
55 total interaction(s) for 40 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 4
  • Co-fractionation: 3
  • PCA: 4

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 27
  • Phenotypic Suppression: 1
  • Positive Genetic: 5
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 152
Molecular Weight (Da) 16,757
Isoelectric Point (pI) 4.5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:228314 to 228772 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..459 228314..228772 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006091
References cited on this page View Complete Literature Guide for DAP1
1) Hand RA, et al.  (2003) Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. Eukaryot Cell 2(2):306-17
2) Mallory JC, et al.  (2005) Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mol Cell Biol 25(5):1669-79