MEX67/YPL169C Summary Help

Standard Name MEX67 1
Systematic Name YPL169C
Feature Type ORF, Verified
Description Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP (1, 2, 3, 4)
Name Description Messenger RNA EXport factor of 67 kDa 1
Chromosomal Location
ChrXVI:230838 to 229039 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All MEX67 GO evidence and references
  View Computational GO annotations for MEX67
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
conditional
Large-scale survey
null
reduction of function
Resources
271 total interaction(s) for 144 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 54
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 45
  • Co-crystal Structure: 1
  • Co-purification: 2
  • Reconstituted Complex: 22
  • Two-hybrid: 7

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Dosage Rescue: 11
  • Negative Genetic: 64
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 3
  • Positive Genetic: 3
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 25
  • Synthetic Rescue: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 599
Molecular Weight (Da) 67,351
Isoelectric Point (pI) 10.03
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:230838 to 229039 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1800 230838..229039 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006090
References cited on this page View Complete Literature Guide for MEX67
1) Segref A, et al.  (1997) Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J 16(11):3256-71
2) Rout MP, et al.  (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
3) Katahira J, et al.  (1999) The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J 18(9):2593-609
4) Gruter P, et al.  (1998) TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell 1(5):649-59