MEX67/YPL169C Summary

MEX67 BASIC INFORMATION

Standard Name	MEX67 1
Systematic Name	YPL169C
Feature Type	ORF, Verified
Description	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP (1, 2, 3, 4)
Name Description	Messenger RNA EXport factor of 67 kDa 1

GO Annotations	All MEX67 GO evidence and references
	View Computational GO annotations for MEX67
Molecular Function
Manually curated	protein binding (IPI) RNA binding (IDA) structural constituent of nuclear pore (IDA)
Biological Process
Manually curated	mRNA export from nucleus (IMP) ribosomal large subunit export from nucleus (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pore (IDA) nuclear RNA export factor complex (IPI)

Mutant Phenotype	All MEX67 Phenotype details and references
Classical genetics
conditional	nuclear export: normal nuclear export: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable

Interactions	MEX67 All interactions details and references
	185 total interaction(s) for 101 unique genes/features.
Physical Interactions	Affinity Capture-MS: 45 Affinity Capture-RNA: 1 Affinity Capture-Western: 25 Co-crystal Structure: 1 Co-purification: 2 Reconstituted Complex: 22 Two-hybrid: 5
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 8 Phenotypic Enhancement: 52 Phenotypic Suppression: 1 Synthetic Growth Defect: 6 Synthetic Lethality: 11 Synthetic Rescue: 5

Sequence Information

ChrXVI:230837 to 229038 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1800	230837..229038	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006090

MEX67 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MEX67

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MEX67]

1)	Segref A, et al. (1997) Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J 16(11):3256-71
2)	Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
3)	Katahira J, et al. (1999) The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J 18(9):2593-609
4)	Gruter P, et al. (1998) TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell 1(5):649-59

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.