Standard Name	MEX67 1
Systematic Name	YPL169C
Feature Type	ORF, Verified
Description	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP (1, 2, 3, 4)
Name Description	Messenger RNA EXport factor of 67 kDa 1

Chromosomal Location	ChrXVI:230838 to 229039 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MEX67
Molecular Function
Manually curated	protein binding (IPI) RNA binding (IDA) structural constituent of nuclear pore (IDA)
Biological Process
Manually curated	mRNA export from nucleus (IMP) ribosomal large subunit export from nucleus (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pore (IDA) nuclear RNA export factor complex (IPI)
High-throughput	integral to membrane (ISM)

Classical genetics
conditional	nuclear export: decreased nuclear export: normal
Large-scale survey
null	cell size: decreased competitive fitness: decreased haploinsufficient inviable
reduction of function	competitive fitness: decreased resistance to sirolimus: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	264 total interaction(s) for 141 unique genes/features.
Physical Interactions	Affinity Capture-MS: 54 Affinity Capture-RNA: 2 Affinity Capture-Western: 45 Co-crystal Structure: 1 Co-purification: 2 Reconstituted Complex: 22 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 11 Negative Genetic: 64 Phenotypic Enhancement: 8 Phenotypic Suppression: 3 Positive Genetic: 3 Synthetic Growth Defect: 11 Synthetic Lethality: 23 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:230838 to 229039 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1800 230838..229039 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006090