Standard Name	AIM44 1
Systematic Name	YPL158C
Alias	GPS1 2
Feature Type	ORF, Verified
Description	Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	Altered Inheritance rate of Mitochondria 1

Chromosomal Location	ChrXVI:254310 to 252034 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for AIM44
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	barrier septum assembly (IMP) protein localization to bud neck (IMP)
Cellular Component
Manually curated	cellular bud neck (IDA)
High-throughput	cellular bud neck (IDA) cellular bud tip (IDA)

Classical genetics
null	cytokinesis: abnormal Rho1p accumulation: decreased Cdc42p distribution: decreased septum formation: abnormal
unspecified	sterol accumulation: decreased
Large-scale survey
null	proton accumulation: decreased proton accumulation: increased competitive fitness: decreased endocytosis: decreased mitochondrial genome maintenance: abnormal resistance to bleomycin: increased resistance to methyl methanesulfonate: increased resistance to sirolimus: increased resistance to tunicamycin: increased resistance to PM02734: decreased resistance to arsenite(3-): decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: increased respiratory growth: decreased rate sporulation: normal viable
overexpression	filamentous growth: decreased invasive growth: absent resistance to sirolimus: increased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	487 total interaction(s) for 326 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Two-hybrid: 7
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 306 Phenotypic Suppression: 1 Positive Genetic: 152 Synthetic Growth Defect: 3 Synthetic Lethality: 4 Synthetic Rescue: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:254310 to 252034 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2277 254310..252034 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006079