KIP2/YPL155C Summary

KIP2 BASIC INFORMATION

Standard Name	KIP2 1
Systematic Name	YPL155C
Feature Type	ORF, Verified
Description	Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle (2, 3)
Name Description	KInesin related Protein 1

GO Annotations	All KIP2 GO evidence and references
	View Computational GO annotations for KIP2
Molecular Function
Manually curated	microtubule motor activity (TAS)
Biological Process
Manually curated	mitotic anaphase B (IMP) negative regulation of microtubule depolymerization (IMP) nuclear migration along microtubule (IMP)
Cellular Component
Manually curated	cytoplasmic microtubule (IDA) kinesin complex (TAS)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All KIP2 Phenotype details and references
Classical genetics
null	cytoskeleton morphology: abnormal nuclear position: abnormal
overexpression	budding index: abnormal cell cycle progression in G2 phase: abnormal
Large-scale survey
null	viable
overexpression	vegetative growth: decreased

Interactions	KIP2 All interactions details and references
	66 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 1 Biochemical Activity: 2 Two-hybrid: 5
Genetic Interactions	Dosage Rescue: 4 Phenotypic Enhancement: 9 Synthetic Growth Defect: 9 Synthetic Lethality: 30 Synthetic Rescue: 3

Sequence Information

ChrXVI:259335 to 257215 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2121	259335..257215	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006076

KIP2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KIP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KIP2]

1)	Roof DM, et al. (1992) Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol 118(1):95-108
2)	Cottingham FR and Hoyt MA (1997) Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol 138(5):1041-53
3)	Carvalho P, et al. (2004) Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Dev Cell 6(6):815-29

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