KES1/YPL145C Summary Help

Standard Name KES1 1
Systematic Name YPL145C
Alias LPI3 , OSH4 2 , BSR3 3 , 4
Feature Type ORF, Verified
Description One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication (4, 5, 6)
Name Description KrE11-1 Suppressor 1
Chromosomal Location
ChrXVI:279699 to 278395 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All KES1 GO evidence and references
  View Computational GO annotations for KES1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
246 total interaction(s) for 174 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Biochemical Activity: 1
  • PCA: 12

Genetic Interactions
  • Dosage Growth Defect: 9
  • Dosage Lethality: 4
  • Dosage Rescue: 2
  • Negative Genetic: 133
  • Phenotypic Enhancement: 6
  • Phenotypic Suppression: 4
  • Positive Genetic: 9
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 16
  • Synthetic Rescue: 18

Resources
Expression Summary
histogram
Resources
Length (a.a.) 434
Molecular Weight (Da) 49,492
Isoelectric Point (pI) 5.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:279699 to 278395 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1305 279699..278395 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006066
References cited on this page View Complete Literature Guide for KES1
1) Jiang B, et al.  (1994) A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10(3):341-53
2) Beh CT, et al.  (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40
3) Cleves AE, et al.  (1991) Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. Cell 64(4):789-800
4) Fang M, et al.  (1996) Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis. EMBO J 15(23):6447-59
5) Li X, et al.  (2002) Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J Cell Biol 157(1):63-77
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61