POC4/YPL144W Summary Help

Standard Name POC4 1
Systematic Name YPL144W
Alias PBA4 2 , DMP1 3
Feature Type ORF, Verified
Description Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions (1, 2, 3)
Name Description PrOteasome Chaperone 1
Chromosomal Location
ChrXVI:280480 to 280926 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All POC4 GO evidence and references
  View Computational GO annotations for POC4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 121 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
96 total interaction(s) for 70 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 13
  • Co-crystal Structure: 2
  • Co-fractionation: 3
  • Co-localization: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 32
  • Positive Genetic: 9
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 5
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 148
Molecular Weight (Da) 16,573
Isoelectric Point (pI) 7.93
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:280480 to 280926 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..447 280480..280926 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006065
References cited on this page View Complete Literature Guide for POC4
1) Le Tallec B, et al.  (2007) 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Mol Cell 27(4):660-74
2) Kusmierczyk AR, et al.  (2008) A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol 15(3):237-44
3) Yashiroda H, et al.  (2008) Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes. Nat Struct Mol Biol 15(3):228-36