FRK1/YPL141C Summary Help

Standard Name FRK1 1
Systematic Name YPL141C
Feature Type ORF, Verified
Description Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description Fatty acyl-CoA synthetase and RNA processing-associated Kinase 1
Chromosomal Location
ChrXVI:286061 to 283464 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All FRK1 GO evidence and references
  View Computational GO annotations for FRK1
Molecular Function
Manually curated
High-throughput
Biological Process
High-throughput
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
Resources
155 total interaction(s) for 127 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 63
  • Protein-RNA: 1
  • Reconstituted Complex: 16
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 6
  • Negative Genetic: 36
  • Positive Genetic: 5
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 865
Molecular Weight (Da) 97,692
Isoelectric Point (pI) 10.27
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:286061 to 283464 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2598 286061..283464 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006062
References cited on this page View Complete Literature Guide for FRK1
1) Breitkreutz A, et al.  (2010) A global protein kinase and phosphatase interaction network in yeast. Science 328(5981):1043-6
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) D'Aquino KE, et al.  (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19(2):223-34
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84