SPP1/YPL138C Summary Help

SPP1 BASIC INFORMATION

Standard Name SPP1 1
Systematic Name YPL138C
Alias CPS40 2 , SAF41 3
Feature Type ORF, Verified
Description Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein (1, 2, 3, 4, 5, 6, 7)
Name Description Set1c, Phd finger Protein
GO Annotations All SPP1 GO evidence and references
    View Computational GO annotations for SPP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All SPP1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SPP1 All interactions details and references
138 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 2
  • Affinity Capture-MS: 51
  • Affinity Capture-Western: 7
  • Biochemical Activity: 2
  • Co-fractionation: 1
  • Co-purification: 2
  • Protein-peptide: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 4
Genetic Interactions
  • Phenotypic Enhancement: 19
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 28
Sequence Information
ChrXVI:292426 to 291365 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1062 292426..291365 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006059

SPP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SPP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPP1]

1) Roguev A, et al.  (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20(24):7137-48
2) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3) Nagy PL, et al.  (2002) A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3. Proc Natl Acad Sci U S A 99(1):90-4
4) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
5) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
6) Cheng H, et al.  (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43
7) Kan J, et al.  (2008) Origin Recognition Complex (ORC) Mediates Histone 3 Lysine 4 Methylation through Cooperation with Spp1 in Saccharomyces cerevisiae. J Biol Chem 283(49):33803-7