Standard Name	SPP1 1
Systematic Name	YPL138C
Alias	CPS40 2 , SAF41 3
Feature Type	ORF, Verified
Description	Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein (1, 2, 3, 4, 5, 6, 7)
Name Description	Set1c, Phd finger Protein

Chromosomal Location	ChrXVI:292427 to 291366 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for SPP1
Molecular Function
Manually curated	chromatin binding (IDA) contributes_to histone methyltransferase activity (H3-K4 specific) (IDA, IMP) methylated histone residue binding (IDA)
Biological Process
Manually curated	chromatin silencing at telomere (IMP) histone H3-K4 methylation (IDA, IMP) regulation of transcription, DNA-dependent (IMP)
Cellular Component
Manually curated	Set1C/COMPASS complex (IPI)

Classical genetics
null	fermentative metabolism: increased flocculation: increased H3K4 modification: decreased histone H3, trimethylated on Lys4 modification: decreased resistance to formamide: decreased resistance to chlorpromazine: decreased resistance to sirolimus: decreased viable
Large-scale survey
null	auxotrophy competitive fitness: increased haploinsufficient resistance to BPS: decreased resistance to benzo[a]pyrene: increased stress resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	187 total interaction(s) for 95 unique genes/features.
Physical Interactions	Affinity Capture-Luminescence: 2 Affinity Capture-MS: 52 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 4 Co-crystal Structure: 1 Co-fractionation: 1 Co-purification: 4 Protein-peptide: 2 Protein-RNA: 1 Reconstituted Complex: 8 Two-hybrid: 18
Genetic Interactions	Negative Genetic: 35 Phenotypic Enhancement: 4 Phenotypic Suppression: 3 Positive Genetic: 5 Synthetic Growth Defect: 20 Synthetic Lethality: 16 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:292427 to 291366 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1062 292427..291366 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006059