Standard Name	RDS2 1
Systematic Name	YPL133C
Feature Type	ORF, Verified
Description	Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole (1, 2, 3)
Name Description	Regulator of Drug Sensitivity 1

Chromosomal Location	ChrXVI:301228 to 299888 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RDS2
Molecular Function
Manually curated	RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IMP)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cellular response to xenobiotic stimulus (IMP) negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source (IMP) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter (IMP) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source (IMP)
Cellular Component
Manually curated	nucleus (IC)
High-throughput	cytoplasm (IDA) nucleus (IDA)

Binding motifs	AANYCCGA 4 [Search intergenic regions for AANYCCGA] CCCCGAB 5 [Search intergenic regions for CCCCGAB]
Regulatory modules	predicted: stressResponse (529)
Resources	ScerTF | UniProbe | YEASTRACT | YeTFaSCo

Classical genetics
null	resistance to Calcofluor White: decreased respiratory metabolism: decreased viable
Large-scale survey
null	competitive fitness: decreased resistance to oligomycin: normal resistance to doxorubicin: decreased resistance to benzo[a]pyrene: increased resistance to cycloheximide: decreased resistance to ketoconazole: decreased resistance to cycloheximide: normal resistance to chloramphenicol: normal resistance to rhodamine 6-G: normal resistance to 4-nitroquinoline N-oxide: normal vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	35 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Biochemical Activity: 10 Reconstituted Complex: 10 Two-hybrid: 5
Genetic Interactions	Negative Genetic: 6 Phenotypic Enhancement: 1 Positive Genetic: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:301228 to 299888 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1341 301228..299888 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006054