TBF1/YPL128C Summary Help

Standard Name TBF1 1
Systematic Name YPL128C
Alias LPI16
Feature Type ORF, Verified
Description Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation (2, 3, 4, 5, 6, 7, 8)
Name Description TTAGGG repeat-Binding Factor 1
Chromosomal Location
ChrXVI:308221 to 306533 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -81.5 cM
Gene Ontology Annotations All TBF1 GO evidence and references
  View Computational GO annotations for TBF1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Large-scale survey
reduction of function
48 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 3
  • Biochemical Activity: 2
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 7
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 562
Molecular Weight (Da) 62,823
Isoelectric Point (pI) 6.59
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:308221 to 306533 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Genetic position: -81.5 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1689 308221..306533 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006049
References cited on this page View Complete Literature Guide for TBF1
1) Brigati C, et al.  (1993) An essential yeast gene encoding a TTAGGG repeat-binding protein. Mol Cell Biol 13(2):1306-14
2) Koering CE, et al.  (2000) Identification of high affinity Tbf1p-binding sites within the budding yeast genome. Nucleic Acids Res 28(13):2519-26
3) Fourel G, et al.  (1999) Cohabitation of insulators and silencing elements in yeast subtelomeric regions. EMBO J 18(9):2522-37
4) Fourel G, et al.  (2001) An activation-independent role of transcription factors in insulator function. EMBO Rep 2(2):124-32
5) Fourel G, et al.  (2002) General regulatory factors (GRFs) as genome partitioners. J Biol Chem 277(44):41736-43
6) Bilaud T, et al.  (1996) The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human. Nucleic Acids Res 24(7):1294-303
7) Preti M, et al.  (2010) The Telomere-Binding Protein Tbf1 Demarcates snoRNA Gene Promoters in Saccharomyces cerevisiae. Mol Cell 38(4):614-620
8) Ribaud V, et al.  (2012) DNA-end capping by the budding yeast transcription factor and subtelomeric binding protein Tbf1. EMBO J 31(1):138-49
9) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66
10) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87