KAP120/YPL125W Summary

KAP120 BASIC INFORMATION

Standard Name	KAP120
Systematic Name	YPL125W
Feature Type	ORF, Verified
Description	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p (1, 2)
Name Description	KAryoPherin

GO Annotations	All KAP120 GO evidence and references
	View Computational GO annotations for KAP120
Molecular Function
Manually curated	structural constituent of nuclear pore (IPI)
Biological Process
Manually curated	protein import into nucleus (IPI)
Cellular Component
Manually curated	cytoplasm (IDA) nuclear pore (IDA) nucleus (IDA)

Mutant Phenotype	All KAP120 Phenotype details and references
Classical genetics
dominant negative	inviable
null	actin cytoskeleton morphology: abnormal endocytosis: decreased
Large-scale survey
null	budding index: decreased polyphosphate accumulation: abnormal competitive fitness: decreased fermentative growth: decreased rate resistance to hygromycin B: decreased toxin resistance: increased transposable element transposition: decreased viable

Interactions	KAP120 All interactions details and references
	97 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Co-purification: 1 Protein-RNA: 1 Reconstituted Complex: 5 Two-hybrid: 12
Genetic Interactions	Phenotypic Enhancement: 29 Phenotypic Suppression: 40 Synthetic Growth Defect: 4

Sequence Information

ChrXVI:313387 to 316485 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..3099	313387..316485	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006046

KAP120 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for KAP120

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for KAP120]

1)	Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
2)	Caesar S, et al. (2006) Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast. Mol Cell Biol 26(8):3170-80

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