RNY1/YPL123C Summary Help

Standard Name RNY1 1
Systematic Name YPL123C
Feature Type ORF, Verified
Description Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity (1, 2)
Name Description RiboNuclease from Yeast 1
Chromosomal Location
ChrXVI:318945 to 317641 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All RNY1 GO evidence and references
  View Computational GO annotations for RNY1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
overexpression
Large-scale survey
null
overexpression
Resources
30 total interaction(s) for 27 unique genes/features.
Physical Interactions
  • Biochemical Activity: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Negative Genetic: 17
  • Positive Genetic: 8
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 434
Molecular Weight (Da) 50,171
Isoelectric Point (pI) 8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:318945 to 317641 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1305 318945..317641 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006044
References cited on this page View Complete Literature Guide for RNY1
1) MacIntosh GC, et al.  (2001) Characterization of Rny1, the Saccharomyces cerevisiae member of the T2 RNase family of RNases: unexpected functions for ancient enzymes? Proc Natl Acad Sci U S A 98(3):1018-23
2) Thompson DM and Parker R  (2009) The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol 185(1):43-50