HOS3/YPL116W Summary Help

HOS3 BASIC INFORMATION

Standard Name HOS3
Systematic Name YPL116W
Feature Type ORF, Verified
Description Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats (1, 2, 3 and see Summary Paragraph)
Name Description Hda One Similar 1
GO Annotations All HOS3 GO evidence and references
    View Computational GO annotations for HOS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All HOS3 Phenotype details and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Interactions HOS3 All interactions details and references
38 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • PCA: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 1
Genetic Interactions
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 6
  • Synthetic Growth Defect: 11
  • Synthetic Rescue: 5
Sequence Information
ChrXVI:329605 to 331698 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2094 329605..331698 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006037

HOS3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HOS3

SUMMARY PARAGRAPH for HOS3

HOS3 encodes a histone deacetylase (1). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 4 and 5. Four other histone deactylases, Rpd3p, Hda1p, Hos1p, and Hos2p, have been identified in yeast; all share sequence similarity (1). Different yeast histone deacetylase complexes affect transcription of distinct, partially overlapping sets of genes (1, 5).

Last updated: 2000-01-10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOS3]

1) Rundlett SE, et al.  (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
2) Carmen AA, et al.  (1999) Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. Proc Natl Acad Sci U S A 96(22):12356-61
3) Robyr D, et al.  (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
4) Mizzen C, et al.  (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81
5) Suka N, et al.  (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9