PEX25/YPL112C Summary 
| Standard Name | PEX25 1 |
|---|---|
| Systematic Name | YPL112C |
| Feature Type | ORF, Verified |
| Description | Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication (1, 2, 3, 4, 5 and see Summary Paragraph) |
| Name Description | PEroXisome related 1 |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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| View Computational GO annotations for PEX25 | |
| Molecular Function | |
| Manually curated |
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| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated |
| Classical genetics | |
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| null | |
| Large-scale survey | |
| null |
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| Resources |
| 33 total interaction(s) for 23 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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| Resources |
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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| Retrieve sequences | |||||||||||||
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000006033 |
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Pex11p, Pex25p, and Pex27p comprise a family of proteins whose members are required for peroxisome biogenesis and play a role in the regulation of peroxisome size and number (3). Pex25p and Pex27p are peroxisomal membrane proteins whose C-termini are similar to the entire Pex11p. Deletion of PEX25 or PEX27 results in enlarged peroxisomes. A partial growth defect on fatty acids of a pex25delta mutant is not exacerbated by the additional deletion of PEX27; however, when PEX11 is also deleted, growth is abolished on all fatty acids. Moreover, the triple mutant strain exhibits a severe peroxisomal protein import defect (3). Overexpression of PEX27 or PEX25 leads to peroxisome proliferation and the formation of small peroxisomes. Overexpression of PEX11 has been reported to produce this same small-peroxisome phenotype (2), and also a similar phenotype in which cells contain an increased number of normal-sized peroxisomes (6).
Last updated: 2005-03-17 
| 1) | Smith JJ, et al. (2002) Transcriptome profiling to identify genes involved in peroxisome assembly and function. J Cell Biol 158(2):259-71 |
| 2) | Tam YY, et al. (2003) Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae. Mol Biol Cell 14(10):4089-102 |
| 3) | Rottensteiner H, et al. (2003) Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis. Mol Biol Cell 14(10):4316-28 |
| 4) | Marelli M, et al. (2004) Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane. J Cell Biol 167(6):1099-112 |
| 5) | Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 |
| 6) | Marshall PA, et al. (1995) Pmp27 promotes peroxisomal proliferation. J Cell Biol 129(2):345-55 |
