NOG1/YPL093W Summary

NOG1 BASIC INFORMATION

Standard Name	NOG1
Systematic Name	YPL093W
Feature Type	ORF, Verified
Description	Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins (1, 2, 3)
Name Description	NucleOlar G-protein 1

GO Annotations	All NOG1 GO evidence and references
	View Computational GO annotations for NOG1
Molecular Function
Manually curated	GTP binding (ISS)
Biological Process
Manually curated	ribosomal large subunit biogenesis (IDA, IMP) ribosomal subunit export from nucleus (IMP, IPI) rRNA processing (IMP)
Cellular Component
Manually curated	nucleolus (IDA) preribosome, large subunit precursor (IDA)
High-throughput	preribosome, large subunit precursor (IDA)

Mutant Phenotype	All NOG1 Phenotype details and references
Classical genetics
null	inviable
reduction of function	vegetative growth: decreased
unspecified	vegetative growth: normal vegetative growth: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable
overexpression	resistance to rapamycin: increased

Interactions	NOG1 All interactions details and references
	237 total interaction(s) for 103 unique genes/features.
Physical Interactions	Affinity Capture-MS: 207 Affinity Capture-Western: 22 Co-purification: 1 Two-hybrid: 4
Genetic Interactions	Dosage Rescue: 3

Sequence Information

ChrXVI:370975 to 372918 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1944	370975..372918	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000006014

NOG1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for NOG1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for NOG1]

1)	Park JH, et al. (2001) A novel nucleolar G-protein conserved in eukaryotes. J Cell Sci 114(Pt 1):173-185
2)	Kallstrom G, et al. (2003) The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol Cell Biol 23(12):4344-55
3)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27

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