GLR1/YPL091W Summary Help

Standard Name GLR1
Systematic Name YPL091W
Alias LPG17
Feature Type ORF, Verified
Description Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Chromosomal Location
ChrXVI:375502 to 376953 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GLR1 GO evidence and references
  View Computational GO annotations for GLR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Pathways
Classical genetics
misexpression
null
overexpression
Large-scale survey
null
Resources
81 total interaction(s) for 61 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 4
  • PCA: 2
  • Protein-peptide: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 3
  • Negative Genetic: 44
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 4
  • Positive Genetic: 6
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 483
Molecular Weight (Da) 53,441
Isoelectric Point (pI) 7.88
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:375502 to 376953 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1452 375502..376953 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006012
References cited on this page View Complete Literature Guide for GLR1
1) Grant CM  (2001) Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions. Mol Microbiol 39(3):533-41
2) Outten CE and Culotta VC  (2004) Alternative start sites in the Saccharomyces cerevisiae GLR1 gene are responsible for mitochondrial and cytosolic isoforms of glutathione reductase. J Biol Chem 279(9):7785-91
3) Outten CE, et al.  (2005) Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae. Biochem J 388(Pt 1):93-101
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Kojer K, et al.  (2012) Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state. EMBO J 31(14):3169-82