Standard Name	MOT1 1
Systematic Name	YPL082C
Alias	BUR3 2 , LPF4
Feature Type	ORF, Verified
Description	Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA (1, 3, 4, 5, 6, 7) Also known as: BTAF1 8
Name Description	Modifier of Transcription 1

Chromosomal Location	ChrXVI:404083 to 398480 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for MOT1
Molecular Function
Manually curated	ATPase activity (IDA) DNA binding (IDA) TBP-class protein binding (IPI)
Biological Process
Manually curated	regulation of RNA polymerase II transcriptional preinitiation complex assembly (IMP) regulation of transcription from RNA polymerase II promoter (IDA) rRNA processing (IMP) transcription of nuclear large rRNA transcript from RNA polymerase I promoter (IDA, IMP)
Cellular Component
Manually curated	nuclear chromosome (IDA)
High-throughput	mitochondrion (IDA) nucleus (IDA)

Classical genetics
conditional	heat sensitivity: increased utilization of carbon source: decreased
Large-scale survey
conditional	colony sectoring: increased
null	inviable resistance to clioquinol: decreased
repressible	chromosome/plasmid maintenance: decreased mitochondrial morphology: abnormal protein transport: abnormal
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	247 total interaction(s) for 141 unique genes/features.
Physical Interactions	Affinity Capture-MS: 129 Affinity Capture-RNA: 4 Affinity Capture-Western: 46 Co-fractionation: 1 Co-localization: 9 Co-purification: 1 Reconstituted Complex: 8 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 8 Synthetic Growth Defect: 8 Synthetic Lethality: 12 Synthetic Rescue: 18
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:404083 to 398480 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..5604 404083..398480 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006003