Standard Name	GPI2 1
Systematic Name	YPL076W
Alias	GCR4 2
Feature Type	ORF, Verified
Description	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein (1, 3)
Name Description	GlycosylPhosphatidylInositol anchor biosynthesis 1

Chromosomal Location	ChrXVI:410443 to 411285 | ORF Map | GBrowse

	View Computational GO annotations for GPI2
Molecular Function
Manually curated	phosphatidylinositol N-acetylglucosaminyltransferase activity (IC, ISA)
Biological Process
Manually curated	GPI anchor biosynthetic process (IDA, IMP)
Cellular Component
Manually curated	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex (IPI, ISA) integral to membrane (ISM)
High-throughput	endoplasmic reticulum (IDA) integral to membrane (ISM)

Classical genetics
conditional	cellular morphology: abnormal endomembrane system morphology: abnormal heat sensitivity: increased sporulation: abnormal vegetative growth: decreased
null	inviable
reduction of function	chitin deposition: increased resistance to aureobasidin A: decreased resistance to Calcofluor White: decreased
Large-scale survey
null	haploproficient inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	87 total interaction(s) for 85 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 2 PCA: 61
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 10 Synthetic Growth Defect: 2 Synthetic Lethality: 9
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:410443 to 411285 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..843 410443..411285 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005997