Standard Name	GRX5 1
Systematic Name	YPL059W
Feature Type	ORF, Verified
Description	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p (1, 2, 3, 4)
Name Description	GlutaRedoXin 1

Chromosomal Location	ChrXVI:444579 to 445031 | ORF Map | GBrowse

	View Computational GO annotations for GRX5
Molecular Function
Manually curated	disulfide oxidoreductase activity (IDA, IGI, IMP, ISS)
Biological Process
Manually curated	cellular response to oxidative stress (IGI, IMP) iron-sulfur cluster assembly (TAS) response to osmotic stress (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA, TAS)
High-throughput	mitochondrion (IDA)

Pathways	glutathione-glutaredoxin system

Classical genetics
null	manganese(2+) accumulation: decreased oxidative stress resistance: decreased Mn-superoxide dismutase (Sod2p) activity: decreased replicative lifespan: decreased resistance to selenomethionine: decreased resistance to Dipyridyl disulfide: decreased resistance to selenite(2-): decreased
overexpression	dessication resistance: increased
Large-scale survey
null	dessication resistance: decreased oxidative stress resistance: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to arsenite(3-): decreased resistance to sorbate: decreased respiratory growth: decreased rate respiratory growth: absent starvation resistance: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	30 total interaction(s) for 26 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Co-localization: 1 PCA: 1 Two-hybrid: 6
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 2 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Growth Defect: 3 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:444579 to 445031 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..453 444579..445031 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005980