ARL3/YPL051W Summary Help

Standard Name ARL3 1
Systematic Name YPL051W
Feature Type ORF, Verified
Description ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1 (1, 2, 3)
Name Description ADP-Ribosylation factor-Like 1
Chromosomal Location
ChrXVI:459963 to 460559 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ARL3 GO evidence and references
  View Computational GO annotations for ARL3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 71 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
434 total interaction(s) for 228 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 7
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 2
  • Co-localization: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 337
  • Phenotypic Enhancement: 1
  • Positive Genetic: 33
  • Synthetic Growth Defect: 25
  • Synthetic Lethality: 22
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 198
Molecular Weight (Da) 22,782
Isoelectric Point (pI) 6.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:459963 to 460559 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..597 459963..460559 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005972
References cited on this page View Complete Literature Guide for ARL3
1) Huang CF, et al.  (1999) Characterization of a novel ADP-ribosylation factor-like protein (yARL3) in Saccharomyces cerevisiae. J Biol Chem 274(6):3819-27
2) Behnia R, et al.  (2004) Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Nat Cell Biol 6(5):405-13
3) Setty SR, et al.  (2004) Golgi targeting of ARF-like GTPase Arl3p requires its Nalpha-acetylation and the integral membrane protein Sys1p. Nat Cell Biol 6(5):414-9