EGD1/YPL037C Summary Help

Standard Name EGD1 1
Systematic Name YPL037C
Feature Type ORF, Verified
Description Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication (2, 3, 4, 5, 6)
Name Description Enhancer of Gal4 DNA binding 1
Chromosomal Location
ChrXVI:481901 to 481428 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All EGD1 GO evidence and references
  View Computational GO annotations for EGD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 13 genes
Classical genetics
Large-scale survey
118 total interaction(s) for 85 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 9
  • Co-fractionation: 3
  • Co-purification: 6
  • PCA: 4
  • Two-hybrid: 12

Genetic Interactions
  • Negative Genetic: 48
  • Phenotypic Enhancement: 1
  • Positive Genetic: 8
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 157
Molecular Weight (Da) 17,020
Isoelectric Point (pI) 6.53
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:481901 to 481428 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..474 481901..481428 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005958
References cited on this page View Complete Literature Guide for EGD1
1) Parthun MR, et al.  (1992) The EGD1 product, a yeast homolog of human BTF3, may be involved in GAL4 DNA binding. Mol Cell Biol 12(12):5683-9
2) George R, et al.  (1998) The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. Proc Natl Acad Sci U S A 95(5):2296-301
3) Shi X, et al.  (1995) The yeast EGD2 gene encodes a homologue of the alpha NAC subunit of the human nascent-polypeptide-associated complex. Gene 165(2):199-202
4) Hu GZ and Ronne H  (1994) Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo. Nucleic Acids Res 22(14):2740-3
5) Reimann B, et al.  (1999) Initial characterization of the nascent polypeptide-associated complex in yeast. Yeast 15(5):397-407
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61