Standard Name	ULP1
Systematic Name	YPL020C
Alias	NIB1 1
Feature Type	ORF, Verified
Description	Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions (2, 3, 4, 5)
Name Description	Ubiquitin-Like Protein

Chromosomal Location	ChrXVI:514178 to 512313 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for ULP1
Molecular Function
Manually curated	cysteine-type peptidase activity (IDA, ISS) SUMO-specific protease activity (IDA, IMP)
Biological Process
Manually curated	G2/M transition of mitotic cell cycle (IMP) protein desumoylation (IDA, IMP)
Cellular Component
Manually curated	nuclear envelope (IDA) nuclear pore (IDA) nucleolus (IDA)

Classical genetics
conditional	Matalpha1p accumulation: increased resistance to doxorubicin: increased
null	inviable
reduction of function	UV resistance: decreased cell shape: abnormal cold sensitivity: increased colony shape: abnormal gamma ray resistance: normal heat sensitivity: increased meiosis: abnormal sumoylated (Smt3p-conjugated) proteins accumulation: increased vegetative growth: abnormal
Large-scale survey
null	inviable vegetative growth: decreased
overexpression	cell cycle progression: abnormal vegetative growth: decreased rate
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	277 total interaction(s) for 212 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 3 Affinity Capture-Western: 11 Biochemical Activity: 1 Co-crystal Structure: 1 PCA: 124 Reconstituted Complex: 4 Two-hybrid: 27
Genetic Interactions	Dosage Rescue: 13 Negative Genetic: 21 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Synthetic Growth Defect: 8 Synthetic Lethality: 29 Synthetic Rescue: 10
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:514178 to 512313 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1866 514178..512313 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005941