CTF19/YPL018W Summary

CTF19 BASIC INFORMATION

Standard Name	CTF19
Systematic Name	YPL018W
Alias	MCM18
Feature Type	ORF, Verified
Description	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly (1, 2, 3)
Name Description	Chromosome Transmission Fidelity 4

GO Annotations	All CTF19 GO evidence and references
	View Computational GO annotations for CTF19
Molecular Function
Manually curated	protein binding (IDA)
Biological Process
Manually curated	attachment of spindle microtubules to kinetochore (IDA, IGI, IMP) chromosome segregation (IGI, IMP)
Cellular Component
Manually curated	COMA complex (IDA) condensed nuclear chromosome kinetochore (IDA, IGI) nucleus (IDA)

Mutant Phenotype	All CTF19 Phenotype details and references
Classical genetics
null	chromosome/plasmid maintenance: abnormal colony sectoring: increased resistance to cincreasin: decreased resistance to staurosporine: decreased resistance to tunicamycin: decreased resistance to Calcofluor White: decreased resistance to chlorpromazine: decreased resistance to bortezomib: decreased
Large-scale survey
null	glycogen accumulation: increased chromosome/plasmid maintenance: decreased competitive fitness: decreased meiosis: abnormal mitotic recombination: increased Rad52-YFP distribution: increased resistance to St. John's Wort extract: decreased resistance to benomyl: decreased resistance to nickel sulfate: increased spore germination: decreased viable

Interactions	CTF19 All interactions details and references
	204 total interaction(s) for 122 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Co-fractionation: 2 Co-localization: 4 Reconstituted Complex: 2 Two-hybrid: 38
Genetic Interactions	Dosage Lethality: 6 Dosage Rescue: 1 Phenotypic Enhancement: 45 Phenotypic Suppression: 3 Synthetic Growth Defect: 28 Synthetic Lethality: 43

Sequence Information

ChrXVI:517649 to 518758 | |

Last Update

Coordinates: 2004-07-21 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1110	517649..518758	2004-07-21	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005939

CTF19 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CTF19

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CTF19]

1)	Hyland KM, et al. (1999) Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle. J Cell Biol 145(1):15-28
2)	Ortiz J, et al. (1999) A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore. Genes Dev 13(9):1140-55
3)	De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21
4)	Spencer F, et al. (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49

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