IRC15/YPL017C Summary Help

Standard Name IRC15 1
Systematic Name YPL017C
Feature Type ORF, Verified
Description Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Increased Recombination Centers 1
Chromosomal Location
ChrXVI:520233 to 518734 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IRC15 GO evidence and references
  View Computational GO annotations for IRC15
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 151 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
93 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Co-purification: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 59
  • Positive Genetic: 4
  • Synthetic Growth Defect: 11
  • Synthetic Lethality: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 499
Molecular Weight (Da) 54,156
Isoelectric Point (pI) 5.87
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:520233 to 518734 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1500 520233..518734 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005938
References cited on this page View Complete Literature Guide for IRC15
1) Alvaro D, et al.  (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Jordan PW, et al.  (2007) Novel roles for selected genes in meiotic DNA processing. PLoS Genet 3(12):e222
4) Keyes BE and Burke DJ  (2009) Irc15 Is a microtubule-associated protein that regulates microtubule dynamics in Saccharomyces cerevisiae. Curr Biol 19(6):472-8