Standard Name	IRC15 1
Systematic Name	YPL017C
Feature Type	ORF, Verified
Description	Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Increased Recombination Centers 1

Chromosomal Location	ChrXVI:520233 to 518734 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for IRC15
Molecular Function
Manually curated	microtubule binding (IDA) S-adenosylmethionine-dependent methyltransferase activity (ISS)
Biological Process
Manually curated	attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation (IMP) meiotic sister chromatid segregation (IMP) microtubule anchoring (IMP) microtubule nucleation (IDA) mitotic recombination (IMP) positive regulation of mitotic cell cycle (IMP)
Cellular Component
Manually curated	microtubule (IDA)
High-throughput	cytoplasm (IDA)

Classical genetics
null	cell cycle progression in M phase: delayed chromosome/plasmid maintenance: abnormal colony sectoring: increased meiosis: abnormal resistance to benomyl: decreased resistance to bortezomib: decreased
Large-scale survey
null	glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased mitotic recombination: increased Rad52-YFP distribution: increased resistance to 1,4-dithiothreitol: decreased resistance to propan-1-ol: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	93 total interaction(s) for 62 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Co-purification: 1 Reconstituted Complex: 1
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 59 Positive Genetic: 4 Synthetic Growth Defect: 11 Synthetic Lethality: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:520233 to 518734 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1500 520233..518734 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005938