HST2/YPL015C Summary Help

Standard Name HST2 1
Systematic Name YPL015C
Feature Type ORF, Verified
Description Cytoplasmic NAD(+)-dependent protein deacetylase; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export (1, 2, 3, 4, 5, 6)
Name Description Homolog of SIR Two (SIR2) 4, 7
Chromosomal Location
ChrXVI:526883 to 525810 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HST2 GO evidence and references
  View Computational GO annotations for HST2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 20 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
38 total interaction(s) for 38 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 3
  • Co-purification: 1

Genetic Interactions
  • Negative Genetic: 6
  • Phenotypic Suppression: 5
  • Synthetic Growth Defect: 20
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 357
Molecular Weight (Da) 39,979
Isoelectric Point (pI) 5.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:526883 to 525810 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1074 526883..525810 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005936
References cited on this page View Complete Literature Guide for HST2
1) Perrod S, et al.  (2001) A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J 20(1-2):197-209
2) Landry J, et al.  (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97(11):5807-11
3) Smith JS, et al.  (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63
4) Brachmann CB, et al.  (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9(23):2888-902
5) Starai VJ, et al.  (2003) Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics 163(2):545-55
6) Wilson JM, et al.  (2006) Nuclear export modulates the cytoplasmic Sir2 homologue Hst2. EMBO Rep 7(12):1247-51
7) Derbyshire MK, et al.  (1996) HST1, a new member of the SIR2 family of genes. Yeast 12(7):631-40