CHL1/YPL008W Summary Help

CHL1 BASIC INFORMATION

Standard Name CHL1
Systematic Name YPL008W
Alias CTF1 1 , LPA9 , MCM12 2
Feature Type ORF, Verified
Description Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p (3)
Name Description CHromosome Loss 4
GO Annotations All CHL1 GO evidence and references
    View Computational GO annotations for CHL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CHL1 Phenotype details and references
Classical genetics
null
repressible
Large-scale survey
null
overexpression
Interactions CHL1 All interactions details and references
146 total interaction(s) for 73 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 46
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 26
  • Synthetic Lethality: 55
Sequence Information
ChrXVI:539382 to 541967 | ORF Map | GBrowse
Gbrowse
Genetic position: -6 cM
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2586 539382..541967 2004-07-21 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005929

CHL1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CHL1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CHL1]

1) Spencer F, et al.  (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49
2) Laha S, et al.  (2006) The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase. Nucleic Acids Res 34(20):5880-91
3) Skibbens RV  (2004) Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics 166(1):33-42
4) Liras P, et al.  (1978) Characterization of a mutation in yeast causing nonrandom chromosome loss during mitosis. Genetics 88(4 Pt 1):651-71