Standard Name	TFC8 1
Systematic Name	YPL007C
Feature Type	ORF, Verified
Description	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 (2, 3, 4)
Name Description	Transcription Factor C 1
Gene Product Alias	tau 60 5

Chromosomal Location	ChrXVI:543848 to 542082 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for TFC8
Molecular Function
Manually curated	contributes_to DNA binding, bending (IDA) contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding (IDA) contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity (IDA) contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding (IDA) contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity (IDA)
Biological Process
Manually curated	5S class rRNA transcription from RNA polymerase III type 1 promoter (IDA) transcription from a RNA polymerase III hybrid type promoter (IDA) transcription from RNA polymerase III promoter (IGI, IMP) transcription from RNA polymerase III type 2 promoter (IDA)
Cellular Component
Manually curated	transcription factor TFIIIC complex (IDA)

Classical genetics
null	inviable
Large-scale survey
null	haploproficient inviable
repressible	cell cycle progression in G1 phase: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	27 total interaction(s) for 15 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-fractionation: 1
Genetic Interactions	Dosage Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:543848 to 542082 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1767 543848..542082 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005928