TFC8/YPL007C Summary Help

Standard Name TFC8 1
Systematic Name YPL007C
Feature Type ORF, Verified
Description Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 (2, 3, 4)
Name Description Transcription Factor C 1
Gene Product Alias tau 60 5
Chromosomal Location
ChrXVI:543848 to 542082 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All TFC8 GO evidence and references
  View Computational GO annotations for TFC8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 2 genes
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
repressible
Resources
27 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Co-fractionation: 1

Genetic Interactions
  • Dosage Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 588
Molecular Weight (Da) 67,683
Isoelectric Point (pI) 6.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:543848 to 542082 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1767 543848..542082 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005928
References cited on this page View Complete Literature Guide for TFC8
1) Deprez E, et al.  (1999) A subunit of yeast TFIIIC participates in the recruitment of TATA-binding protein. Mol Cell Biol 19(12):8042-51
2) Conesa C, et al.  (1993) On the subunit composition, stoichiometry, and phosphorylation of the yeast transcription factor TFIIIC/tau. J Biol Chem 268(24):18047-52
3) Geiduschek EP and Kassavetis GA  (2001) The RNA polymerase III transcription apparatus. J Mol Biol 310(1):1-26
4) Schultz P, et al.  (1989) The two DNA-binding domains of yeast transcription factor tau as observed by scanning transmission electron microscopy. EMBO J 8(12):3815-24
5) Jourdain S, et al.  (2003) The tau95 subunit of yeast TFIIIC influences upstream and downstream functions of TFIIIC.DNA complexes. J Biol Chem 278(12):10450-7