Standard Name	LSP1 1, 2
Systematic Name	YPL004C
Feature Type	ORF, Verified
Description	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family (2, 3, 4)
Name Description	Long chain bases Stimulate Phosphorylation 2

Chromosomal Location	ChrXVI:551657 to 550632 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for LSP1
Molecular Function
Manually curated	lipid binding (IDA)
Biological Process
Manually curated	endocytosis (IGI, IMP) negative regulation of protein kinase activity (IMP) response to heat (IMP)
Cellular Component
Manually curated	eisosome (IDA)
High-throughput	cytoplasm (IDA) mitochondrial outer membrane (IDA) mitochondrion (IDA) plasma membrane (IDA)

Classical genetics
null	endocytosis: decreased rate heat sensitivity: decreased Slt2p modification: increased
overexpression	heat sensitivity: decreased
Large-scale survey
null	competitive fitness: decreased haploproficient heat sensitivity: increased resistance to benzo[a]pyrene: decreased resistance to amitrole: decreased resistance to cycloheximide: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	150 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 78 Affinity Capture-RNA: 5 Affinity Capture-Western: 2 Biochemical Activity: 3 Co-crystal Structure: 1 Co-localization: 4 PCA: 23 Reconstituted Complex: 2 Two-hybrid: 13
Genetic Interactions	Negative Genetic: 15 Phenotypic Enhancement: 2 Positive Genetic: 1 Synthetic Haploinsufficiency: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Mass Spec | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:551657 to 550632 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1026 551657..550632 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005925