Standard Name	HAT1 1
Systematic Name	YPL001W
Feature Type	ORF, Verified
Description	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair (1, 2, 3, 4, 5, 6)
Name Description	Histone AcetylTransferase 1
Gene Product Alias	KAT1 7

Chromosomal Location	ChrXVI:554605 to 555729 | ORF Map | GBrowse

	View Computational GO annotations for HAT1
Molecular Function
Manually curated	histone acetyltransferase activity (IDA, IMP) contributes_to histone binding (IDA)
Biological Process
Manually curated	chromatin silencing at telomere (IGI) histone acetylation (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) histone acetyltransferase complex (IDA, IPI) nucleus (IDA)

Classical genetics
null	silencing: decreased viable
Large-scale survey
null	chronological lifespan: decreased competitive fitness: decreased haploproficient resistance to bleomycin: decreased resistance to dimethyl sulfoxide: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	136 total interaction(s) for 66 unique genes/features.
Physical Interactions	Affinity Capture-MS: 81 Affinity Capture-Western: 14 Co-fractionation: 1 Co-purification: 1 Reconstituted Complex: 1 Two-hybrid: 2
Genetic Interactions	Negative Genetic: 11 Phenotypic Enhancement: 3 Synthetic Growth Defect: 19 Synthetic Lethality: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:554605 to 555729 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1125 554605..555729 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005922