HAT1/YPL001W Summary Help

HAT1 BASIC INFORMATION

Standard Name HAT1 1
Systematic Name YPL001W
Feature Type ORF, Verified
Description Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair (1, 2, 3, 4, 5, 6)
Name Description Histone AcetylTransferase 1
Gene Product Alias KAT1 7
GO Annotations All HAT1 GO evidence and references
    View Computational GO annotations for HAT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All HAT1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions HAT1 All interactions details and references
113 total interaction(s) for 56 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 73
  • Affinity Capture-Western: 13
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 2
Genetic Interactions
  • Phenotypic Enhancement: 4
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 4
Sequence Information
ChrXVI:554602 to 555726 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-21 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1125 554602..555726 2004-07-21 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005922

HAT1 RESOURCES

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SGD ORF map
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  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for HAT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HAT1]

1) Kleff S, et al.  (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270(42):24674-7
2) Dutnall RN, et al.  (1998) Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell 94(4):427-38
3) Ruiz-Garcia AB, et al.  (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605
4) Parthun MR, et al.  (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94
5) Kelly TJ, et al.  (2000) Type B histone acetyltransferase Hat1p participates in telomeric silencing. Mol Cell Biol 20(19):7051-8
6) Qin S and Parthun MR  (2002) Histone H3 and the histone acetyltransferase Hat1p contribute to DNA double-strand break repair. Mol Cell Biol 22(23):8353-65
7) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6