RAD17/YOR368W Summary Help

RAD17 BASIC INFORMATION

Standard Name RAD17
Systematic Name YOR368W
Feature Type ORF, Verified
Description Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins (1, 2, 3, 4)
Name Description RADiation sensitive
GO Annotations All RAD17 GO evidence and references
    View Computational GO annotations for RAD17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All RAD17 Phenotype details and references
Classical genetics
null
reduction of function
unspecified
Large-scale survey
null
Interactions RAD17 All interactions details and references
147 total interaction(s) for 76 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-Western: 7
  • Co-fractionation: 4
  • Co-purification: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 41
  • Phenotypic Suppression: 9
  • Synthetic Growth Defect: 36
  • Synthetic Lethality: 21
  • Synthetic Rescue: 11
Sequence Information
ChrXV:1026841 to 1028046 | ORF Map | GBrowse
Gbrowse
Genetic position: 214 cM
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1206 1026841..1028046 2006-01-05 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005895

RAD17 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for RAD17

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RAD17]

1) Parker AE, et al.  (1998) A human homologue of the Schizosaccharomyces pombe rad1+ checkpoint gene encodes an exonuclease. J Biol Chem 273(29):18332-9
2) Lydall D, et al.  (1996) A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Nature 383(6603):840-3
3) Majka J and Burgers PM  (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A 100(5):2249-54
4) Shinohara M, et al.  (2003) The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast. Genetics 164(3):855-65