Standard Name	RAD17
Systematic Name	YOR368W
Feature Type	ORF, Verified
Description	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins (1, 2, 3, 4)
Name Description	RADiation sensitive

Chromosomal Location	ChrXV:1026843 to 1028048 | ORF Map | GBrowse
	Genetic position: 214 cM

	View Computational GO annotations for RAD17
Molecular Function
Manually curated	double-stranded DNA binding (IDA)
Biological Process
Manually curated	DNA damage checkpoint (IMP) double-strand break repair (IMP) reciprocal meiotic recombination (IMP)
Cellular Component
Manually curated	checkpoint clamp complex (IDA) nucleus (IPI)

Classical genetics
null	RAD30 accumulation: increased UV resistance: decreased chromosome/plasmid maintenance: abnormal gamma ray resistance: decreased mutation frequency: increased oxidative stress resistance: decreased resistance to methyl methanesulfonate: decreased resistance to 4-aminofolic acid: decreased resistance to selenite(2-): decreased spore germination: decreased
reduction of function	mutation frequency: decreased resistance to 4-nitroquinoline N-oxide: decreased
unspecified	UV resistance: decreased
Large-scale survey
null	UV resistance: decreased competitive fitness: decreased gamma ray resistance: decreased resistance to methyl methanesulfonate: decreased resistance to fenpropimorph: decreased resistance to camptothecin: decreased resistance to bleomycin: decreased resistance to hydroxyurea: decreased resistance to ethanol: decreased resistance to 5-fluorouracil: decreased resistance to tunicamycin: increased resistance to mycophenolic acid: increased resistance to fluconazole: increased resistance to caffeine: increased resistance to cycloheximide: increased resistance to cycloheximide: decreased resistance to sirolimus: decreased resistance to sodium selenide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	241 total interaction(s) for 131 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 8 Co-fractionation: 4 Co-purification: 2 Reconstituted Complex: 2 Two-hybrid: 9
Genetic Interactions	Dosage Growth Defect: 2 Dosage Lethality: 1 Dosage Rescue: 2 Negative Genetic: 63 Phenotypic Enhancement: 25 Phenotypic Suppression: 11 Positive Genetic: 19 Synthetic Growth Defect: 56 Synthetic Lethality: 17 Synthetic Rescue: 15
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:1026843 to 1028048 | ORF Map | GBrowse
	Genetic position: 214 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1206 1026843..1028048 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005895